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The interests of the Santini Miletic Research Group

Dental Material Sciences * Pulp Biology * Research Methodology

Recent research has focused on

dental resin based composites and adhesives using Raman Spectroscopy, High performance liquid chromatography,

Scanning and Transmission Electron Microscopy

Atomic Force Microscopy

Professor Ario Santini

BDS, DDS, PhD, DipFMed, DGDP (RCS,Eng), FFGDP(UK),FADM Director of Biomaterial Research, The Edinburgh Postgraduate Dental Institute, The University of Edinburgh, UK.

v.Professor, School of Dentistry, University of Belgrade, Belgrade, Serbia: former v. Professor, Faculty of Medicine and Surgery, University of Sassari, Sassari, Italy:

Fellow of the Academy of Dental Materials.

Research Interests: Dental Material Sciences, Dental Resin Based Composites and Adhesives, Raman Spectroscopy, High Performance Liquid Chromatography, Pulp Biology and Research Methodology.

General Dental Practitioner, Practice Based Research.

ariosantini_hotmail.com

Dr Vesna Miletic BDS, MSc, PhD is a graduate of the Belgrade Dental School, University of Belgrade, Belgrade, Serbia.

Research interests are related to the Chemical and Physical Properties of Resin-based Restorative Materials, Raman Spectroscopy, High performance Liquid Chromatography and Research Methodology.

vesna.miletic_gmail.com

Contact The Santini Miletic Research Group by email: info_santinimiletic.com

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Professor Ario Santini

BDS, DDS, PhD, DipFMed, DGDP(RCS Eng),FFGDP(UK) FADM

Professor Santini was a founder member of the Faculty of General Dental Practitioners. This faculty is now widely recognised by government and other important bodies as the academic home of general dental practice.

Previous Positions:

* Senior Lecturer. Edinburgh University, Department Conservative Dentistry.

* Senior, Lecturer. Edinburgh University, Department Pathology. Forensic Medicine Unit.

* National Dental Advisory Committee. (Scotland)

click here for full report The availability and uptake of services for the dentally anxious.

A report of a working group of the National Dental Advisory Committee.

* Scottish School of Primary Care. Steering Group Member.

Editorial Board Primary Dental Care.

Associate Editor, Serbian Dental Journal.

Director Biomaterial Research

The University of Edinburgh

Edinburgh Postgraduate Dental Institute

Lauriston Buildings (4th floor)

Lauriston Place

Edinburgh EH3 9HA

Chair Research

Faculty of General Dental Practice (UK)

35-43 Lincoln's Inn Fields

London, WC2A 3PE

V. Professor, The University of Belgrade

School of Dentistry, Dept .Restorative Dentistry and Endodontics

4, Rankeova str. 11000 Belgrade Serbia

former V. Professor, Faculty of Medicine and Surgery, University of Sassari, Sassari, Italy:

Member: National Institute of Health Research: Oral & Dental Speciality Group.

Member: Scottish Dental Practice Based Research Network Steering Group.

1.Journal Biomedical Materials Research. Part A.2.Archives Oral Biology3.Dental Materials.4.Journal of Dentistry.5.European Journal of Oral Sciences.6.Journal of Biomaterials Science.7.International Journal of Dentistry.8.Journal Applied Oral Science.9.Acta Odontologica Scandinavica.10.International Journal of Paediatric Dentistry.11.International Journal Modern Physics (B)12.Primary Dental Care.13.The Angle Orthodontist14.Journal Open Dentistry.15.Serbian Dental Journal.16.Balkan Journal Dentistry.17.Indian Journal Dental Research
Selected papers - scroll down for moreEaton KA, Santini A. An introduction to research for primary dental care clinicians part 3: stage 5. Writing a protocol. Prim Dent Care 2011;18(2):91-4. Toy A, Eaton KA, Santini A. An introduction to research for primary dental care clinicians Part 2: Stage 4. Planning the study. Prim Dent Care 2011;18(1):36-40.Farbey A, Eaton KA, Santini A. An introduction to research for primary dental care clinicians part 1: the first three stages in a research project. Prim Dent Care 2010;17(4):168-172Eaton KA, Santini A. Report of the UK Oral and Dental Health Research Summit. Prim Dent Care. 2010;17(3):123-6. Santini A. Current status of visible light activation units and the curing of light-activated resin-based composite materials. Dent Update 2010; 37: 214-6, 218-20, 223-7.Miletic V, Santini A, Trkulja I. Quantification of monomer elution and carbon-carbon double bonds in dental adhesive systems using HPLC and micro-Raman spectroscopy. J Dent 2009;37(3):177-84.Santini A, Miletic V. Comparison of the hybrid layer formed by Silorane adhesive, one-step self-etch and etch and rinse systems using confocal micro-Raman spectroscopy and SEM. J Dent. 2008;36(9):683-91.Santini A, Miletic V. Quantitative micro-Raman assessment of dentine demineralization, adhesive penetration, and degree of conversion of three dentine bonding systems. Eur J Oral Sci. 2008;116(2):177-83.McFadzean RW, Gibson E, Newcombe RF, Nataraja R, Santini A. Resin Based Composites and Dentine Bonding Agents.- Which, Who and Why? - A Study in the East of Scotland.Primary Dental Care.2009;2:59-66.Santini A, Rajab A. Pulham C, Ibbetson R. The effect of a 10% carbamide peroxide bleaching agent on the phosphate concentration of tooth enamel assessed by Raman Spectroscopy.Dent Traumatol. 2008;24:220-223.Gilchrist F, Santini A, Harley K, Deery C. The use of micro-Raman spectroscopy to differentiate between sound and eroded primary enamel.Inter J Paed Dent 2007;17:274-280.Santini A., Pulham C., Milia E., Rajab A. The effect of bleaching on the phosphate concentration of tooth enamel assessed by Raman spectroscopy.Italian Journal Conservative Dentistry 2006;1:107-08.Salim S, Santini A, Husham A. An in-vitro study of microleakage around class v cavities bonded with a self-etching material versus a conventional two-bottle system.Prim Dent Care. 2006;13:107-11.53. Santini A, Ivanovic V, Tan CL, Ibbetson RJ. Effect of prolonged thermal cycling on microleakage around Class V cavities restored with glass-ceramic inserts with different coefficients of thermal expansion: an in vitro study.Prim Dent Care. 2006;13:147-53.54. Usai P., Campus G., Gallottini L., Santini A., Milia E.: An ultrastructural study of the variability of interfacial morphology between a self etching system and carious and sclerotic dentin.Italian Journal Conservative Dentistry 2006;1:113.2005.47. Salim S, Santini A, Ibbetson R. Microleakage around glass ceramic inserts (Megafiller, Standardformen) luted with a high viscous composite (Tetric) or a flowable composite (CrystalEssence).Esthet Restor Dent 2005;17:30-38.48. Milia E, Gallottini G, Nucci C, Santini A. Morphological and quantitative aspects of the interdiffusion zone created by self-etching systems applied to carious dentine.Italian Journal Conservative Dentistry 2005;3:41-48.49. Tan CL, Santini A: Marginal microleakage around class V cavities restored with glass ceramic inserts of different coefficients of thermal expansion.J Clin Dent 2005; 16:26-31.50. Milia E, Santini A, Gallottini G, Prati C. TEM study of self-etching agents with differing pH values.Italian Journal Conservative Dentistry 2005; 4;32-37.2004.41. Santini A, Ivanovic V, Milia E. Marginal Microleakage and Interfacial morphology of Self-etching adhesives of different pH values around Class V Resin Composite Restorations.Italian Journal of Conservative Dentistry 2004;4:214-222.42. Milia E, Valle D, Solinas G, Lai V, Santini A. Adhesion of an antibiotic containing self-etching agent to infected and non-infected dentine.Italian Journal of Conservative Dentistry 2004;2:77-78.43. Milia E, Santini A. An in-vivo TEM study of the action of an antibiotic containing self-etching agent in sclerotic dentine.Italian Journal of Conservative Dentistry 2004;2:78-79.44. Santini A, Milia E. Microleakage around a low-shrinkage composite cured with a high-performance light.Am J Dent 2004;17:118-122.45. Santini A, Ivanovic V, Ibbetson R, Milia E. Influence of Cavity Configuration on Microleakage around Class V Cavities Bonded with one of Seven Self-etching agents.J Esthet Restor Dent 2004; 16:128-135.46. Santini A, Ivanovic V, Ibbetson R, Milia E. Influence of marginal bevels on Microleakage around Class V cavities Bonded with Seven Self-Etching agents.Am J Dent 2004;17:257-61.2003.40. Milia E, Santini A. Ultrastructural transmission electron microscopy (TEM) study of hybrid layers formed beneath a one-bottle system using the total-etch technique and a self-etching system.Quintessence Int. 2003;34:447-452.2001.38. Santini A, Plasschaert AJM, Mitchell S. Effect of composite resin placement techniques on the microleakage of two self-etching dentin bonding agents.American Journal of Dentistry. 2001:14;132-136.39. Santini A, Plasschaert AJM, Mitchell S. Microleakage of Tetric Ceram/ Excite and Ariston pHc/Ariston Liner.American Journal of Dentistry. 2001;14:309-313.1999.36. Santini A, Microleakage of resin-based composite restorations using different solvent-based dentin bonding agents and methods of drying acid-etched dentin.American Journal of Dentistry. 1999; 12: 194-200.37. Santini A, Plasschaert AJM, Mitchell S. Marginal leakage of filled dentin adhesives used with wet and dry bonding techniques.American Journal of Dentistry. 2000:13:93-97.1998.31. Santini A. Biocompatibility of dentine-bonding agents: (1) Factors associated with function.Primary Dental Care. 1998;5:15-19.32. Santini A. Biocompatibility of dentine-bonding agents: (2) Pulpal considerations.Primary Dental Care. 1998:5:69-72.33. Santini A, Mitchell S. A SEM study of the effect of Gluma CPS bonding system on dentinal smear layers produced by different bur types and rotational speeds and the resin-dentin interface.Quintessence International 1998;29:737-747.34. Santini A, Mitchell. Effect of wet and dry bonding techniques on marginal leakage.American Journal of Dentistry. 1998; 1 1:219-224.35. Santini A, Mitchell S. Microleakage of resin composites bonded with three water-based dentin bonding agents.Journal of Esthetic Dentistry. 1998. 10;296-304.1996.29. Santini A. The diagnosis, classification and treatment of acute dental pain by UK general dental practitioners: Results of a survey.Primary Dental Care. 1996;3:24-27.30. Santini A, Ivanovic V. The quantification of tertiary dentine formation in response to materials commonly placed in deep cavities in general dental practice in the UK.Primary Dental Care. 1996;3:14-22.1994.28. Santini A. Research - the key to the future.Prim Dent Care 1994 1:4. (editorial)1993.27. Santini A. The clinical investigation of electronic anaesthesia using CEDATA.Postgraduate Dentist. 1993:3:154-160.1991.24. Santini A. Electronic Targeted Anaesthesia.Dental Practice 1991; ll: 18-21.25. Ivanovic V, Santini A, Filipovic V, Pajic M. Pulpo-dentinal responses to newer dentin bonding agents.Journal of Dental Research. 199 1;70; 107.26. Santini A, Ivanovic V. Effect of smear layer on strength of dentine bonding systems.Journal of Dental Research. 1991, 70;749.1990.22. Santini A, Land M, A comparison of the position of the mental foramen in Chinese and British mandibles.Acta Anatomic 1990; 137: 208-212.23. Santini A, Land M. The accuracy of simple ordinal scoring of tooth attrition in age assessment.Forensic Science International 1990; 48:175-184.1988.21. Santini A. A Compound Composite Odontome in a 14th Century Scottish Skull.The Paleopathology Digest 1988; 58:9-10.1989.20. Ivanovic V, Santini A. Rate of Formation of Tertiary Dentine in Dogs' Teeth in response to lining materials.Oral Surgery Oral Medicine Oral Pathology 1989; 67:684-688.1987.18. Ivanovic V, Santini A. Tertiary Dentine Formation in Dogs' Teeth in Response to Lining Materials.Journal of Dentistry 1987; 15:85-87.19. Callis P, Santini A. Tissue Response to Retrograde Fillings in the Ferret Canine: A Comparison of a Glass lonomer Cement and Gutta Percha Sealer.Oral Surgery Oral Medicine Oral Pathology 1987; 64:475-479.1986.15. Santini A. Potentiometric Study of Dentine Permeability.Caries Research 1986; 20:341-343.16. Santini A. A Long Term Clinical Assessment of Pulpotomies with Calcium Hydroxide Containing Ledermix in Permanent Premolars and Molars.Acta Odontologia Pediatrica 1986; 7:45-50.17. Santini A. Obturation of Root Canals by the Standardised and Step-back Techniques.Endodontics and Dental Traumatology. 1986;3:68-74.1985.12. Santini A. Intraoral Comparison of Calcium Hydroxide (Calnex) alone and in Combination with Ledermix in First Permanent Mandibular Molars Using Two Direct Inspection Criteria.Journal of Dentistry 1985; 13:52-59.13. Callis P, Santini A. A suggested Role for Polymorphonuclear Leucocytes in the Perpetuation of Periapical Disease.Oral Surgery Oral Medicine Oral Pathology 1985; 59:88-90.14. Callis P, Santini A. 'The Response of Human Roots Filled with Collagen/Hydroxyapatite Paste Implanted Subcutaneously in Rats and Guinea Pigs.International Endodontic Journal 1985; 18:267-271.1983.11. Santini A. Assessment of the Pulpotomy Technique in Human First Permanent Mandibular Molars.British Dental Journal 1983; 155:151-154.1982.10. Santini A. Hepatitis in Dentistry: A Review.Quintessence International 1982; 10: 1 145-1148.1981.6. Santini A. Traiternent des Caries Profondes et Maintien de la Vitalite Pulpaire (part 1).Odontologia 1981; 3:13-17.7. Santini A. Traitement des Caries Profondes et Maintien de la Vitalite Pulpaire (part 2).Odontologia 1981 4:11-17.8. Santini A. Valoracion Clinica de la Teenica de Pulpatomia (part 1)Quintaesencia en Espanol 1981; 13:439-410.9. Santini A. Valoracion Clinica de la tecnica de pulpotomia (part 2)Quintaesencia en Espanol 1981; 3:533-536.1980.1. Santini A. The Management of the Deep Carious Lesion and Maintenance of Pulp Vitality. (part 1).Quintessence International 1980; 3:13-17.2. Santini A. The Management of the Deep Carious Lesion and Maintenance of Pulp Vitality (part 2)Quintessence International 1980; 4:17-23.3. Santini A. The Management of the Deep Carious Lesion and Management of Pulp Vitality (part 3)Quintessence International 1980; 5:21-25.4. Santini A. The Clinical Assessment of the Pulpotomy Technique on Teeth of Various Post-operative age groups (part 1).Quintessence International 1980; 11:73-77.

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Dr Vesna Miletic BDS, MSc, PhD

Graduated in dentistry at the University of Belgrade, School of Dentistry, 2000.

MSc (Univ. of Belgrade, Serbia) 2005. - Finite element analysis of the occlusal loading of teeth.

PhD (Univ. of Edinburgh, UK) 2010. - Micro-Raman spectroscopic studies on the adhesive-dentine interface and the degree of conversion of dental adhesives.

Post-doctoral Research Fellow, (Univ. of Edinburgh, UK) 2011

Referee for the following Journals

Dental Materials

Journal of Biomedical Materials Research: Part B - Applied Biomaterials

Journal of Adhesive Dentistry

Clinical Oral Investigations

Quintessence International

Journal of Dentistry and Oral Hygiene

Research projects

Development and application of methods and materials for monitoring new organic contaminants, toxic compounds and heavy metals. Project #172007 supported by the Ministry of Science, Republic of Serbia

Clinical lecturer

The University of Belgrade

School of Dentistry

Restorative Dentistry and Endodontics

4, Rankeova str.

11000 Belgrade Serbia

Personal web pages: www.miletic.me
Selected papers - scroll down for more- Miletic V, Beljic-Ivanovic K, Ivanovic V. Clinical reproducibility of three electronic apex locators. [In Press] Int Endod J. 2011 May 21. doi: 10.1111/j.1365-2591.2011.01897.x. - Manojlovic D, Radisic M, Vasiljevic T, Zivkovic S, Lausevic M, Miletic V. Monomer elution from nanohybrid and ormocer-based composites cured with different light sources. Dent Mater 2011;27(4):371-8. - Milosevic M, Miletic V, Mitrovic N, Manojlovic D, Savic Stankovic T, Maneski T. Measurement of local deformation fields in dental composites using 3D optical system. Chem Listy 2011;105:s751-s753.- Miletic V, Santini A, Trkulja I. Quantification of monomer elution and carbon-carbon double bonds in dental adhesive systems using HPLC and micro-Raman spectroscopy. J Dent 2009;37(3):177-84.- Miletic V, Ivanovic V, Dzeletovic B, Lezaja M. Temperature Changes in Silorane-, Ormocer-, and Dimethacrylate-Based Composites and Pulp Chamber Roof during Light-Curing. J Esthet Restor Dent 2009;21(2):122-131.- Vujaskovic M, Karadzic B, Miletic V. Root canal treatment of mandibular second premolar tooth with taurodontism. Srp Arh Celok Lek. 2008 May-Jun;136(5-6):280-3.- Grga Dj, Miletic V, Jelic M. SEM study of Thermafil obturation technique with five endodontic sealers. Balk J Stom 2007;11:123-128.- Grga Dj, Miletic V. Dental education for left-handed students. Serb Dent J 2006;53:138-143.- Miletic V, Grga Dj. Computer literacy and access to the Internet among dental students. Serb Dent J 2004;51:97-102.- Zivkovic S, Jefic B, Miletic V, Lazic V. Radiographic analysis of restorations using individually prepared cores on endodontically treated teeth. Serb Dent J 2002;49:14-9.

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Professor Vladimir Ivanovic BDS, MSc, PhD

Former Vice Dean, School of Dentistry Belgrade University, Serbia. Board member of the European Endodontic Forum. President of the Serbian Endodontic Society.

Research interests: Composite and Adhesive Systems, Reparative Dentinogenesis and Pulp Biology and Endodontology.

vladaivanovic_hotmail.com

Professor Egle Milia MD, BDS

Professor and Director of Operative Dentistry

School of Dentistry, University of Sassari, Italy

Board member of the Italian Society of Conservative Dentistry.

Research interests: Adhesive Dentistry, Adhesive Systems, Pulp Biology, Tooth tissue microanatomy using Transmission electron microscopy

emilia_uniss.it
Selected papersSantini A, Ivanović V, Ibbetson R, Milia E. Influence of marginal bevels on Microleakage around Class V cavities Bonded with Seven Self-Etching agents.Am J Dent 2004;17:257-61.Ivanović V, Pajić M, Filipović V, Santini A.: Changes in dentine permeability after application of indirect pulp capping agents in vitro conditions.Stom Glas Srbije, 1987, 34, 4: 307-316.Ivanović V, ivković S, Radosavljević B, Santini A.: Testing of antibacterial effect of different dentin conditioners.Stom Glas Srbije, 1996, 43: 77-81.Ivanović V, Santini A. Rate of Formation of Tertiary Dentine in Dogs' Teeth in response to lining materials.Oral Surgery Oral Medicine Oral Pathology 1989; 67:684-688.Ivanović V, Santini A. Tertiary Dentine Formation in Dogs' Teeth in Response to Lining Materials.Journal of Dentistry 1987; 15:85-87.
Selected papersMilia E, Valle D, Solinas G, Lai V, Santini A. Adhesion of an antibiotic containing self-etching agent to infected and non-infected dentine.Italian Journal of Conservative Dentistry 2004;2:77-78.Santini A, Milia E. Microleakage around a low-shrinkage composite cured with a high-performance light.Am J Dent 2004;17:118-122.Santini A, Ivanovic V, Ibbetson R, Milia E. Influence of Cavity Configuration on Microleakage around Class V Cavities Bonded with one of Seven Self-etching agents.J Esthet Restor Dent 2004; 16:128-135.Milia E, Santini A. Ultrastructural transmission electron microscopy (TEM) study of hybrid layers formed beneath a one-bottle system using the total-etch technique and a self-etching system.Quintessence Int. 2003;34:447-452.

Dr Peter Kew MA, PhD, C Eng

Senior Lecturer in the Department of Mechanical Engineering, Heriot-Watt University, Edinburgh, Scotland, UK

Research interests: energy, thermodynamics, and heat transfer in confined spaces and from small components.

p.a.kew_hw.ac.uk

Dr Ivan Trkulja BSc, MSc, PhD

Technology & Projects Department, Syngenta Crop Protection AG, Switzerland. Postdoctoral Fellowship at the University of Edinburgh

Research interests: DNA Chemistry, DNA Sequencing Technologies, SNP Detection, RNA interference, Materials in Dental Research.

trkulja_gmail.com
Selected papersC Millen, M Ormond, G Richardson, A Santini, P Kew, V Miletic. A study of temperature rise in the pulp chamber during composite polymerization with different light curing units.Journal of Contemporary Dental Practice. 2007;8:29-37.
Selected papersMiletic V, SantiniA, Trkulja I. Quantification of monomer elution and carbon-carbon double bonds in dental adhesive systems using HPLC and micro-Raman spectroscopy.J Dent. 2009;37:177-184.I.Trkulja and R. Häner, Monomeric and Hetero-dimeric Triple Helical Mimics.J. Am. Chem. Soc., 2007, 129, 7982-7989.I. Trkulja, S.M. Biner, S. Langenegger and R. Häner, A Molecular Probe for the Detection of Homopurine sequences.ChemBioChem 2007, 8, 25-27.

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Professor Mark Bradley

Professor Colin Pulham
Professor Mark Bradley graduated with a first class degree in chemistry and a D.Phil from University of Oxford. This was followed by a period of post-doctoral research at Harvard Medical School in the area of molecular biology. He was at the University of Southampton from 1992-2004 as a Royal Society University Research Fellow (1992-1999), during which time at the age of 33 he was awarded a personal chair in Combinatorial Chemistry (1997). In 2005 he took up his current position as Professor of High-Throughput Chemical Biology in Edinburgh. He is a fellow of the Royal Society of Edinburgh and of the Royal Society of Chemistry. His group has published over 220 research articles and 20 patents. His research interests are focused on the application of the tools and techniques of chemistry to answer and solve biological problems and address needs, typically with a high-throughput twist.; the development of non-DNA based microarray platforms for cell and enzymatic based assays and the development of chemistries that enable highly efficient cellular delivery of proteins, nucleic acids, sensors and small molecules. Selected papers:- Screening of a Combinatorial Homing Peptide Library for Selective Cellular Delivery. Angewandte Chemie Int. Ed., 2011, 50, 6133-6136. (Angewandte Chemie, 2011, 123, 6257-6260 - Polymers for the rapid and effective activation and aggregation of platelets. Biomaterials, 2011, 32, 7034-7041 - Palladium-mediated Intracellular Chemistry. Nature Chemistry, 2011, 3, 241-245 - Unbiased screening of polymer libraries to define novel substrates for functional hepatocytes with inducible drug metabolism. Stem Cell Research, 2011, 6, 92-102
Professor Colin Pulham graduated with a BA(Hons) and a D.Phil. from the University of Oxford. After a further two years postdoctoral research in Oxford, he moved to the University of Edinburgh in 1992 as a Royal Society University Research Fellow before being appointed as a lecturer in inorganic chemistry in 1996 and senior lecturer in 2001. He currently holds a personal chair in High-Pressure Chemistry and is the Director of Teaching in the School of Chemistry at the University of Edinburgh. He is also a member of the Centre for Science at Extreme Conditions (CSEC) at Edinburgh and has research interests in the study of the effects of high pressure on molecular compounds such as pharmaceuticals and energetic materials (explosives, propellants), using a combination of spectroscopic (Raman and infrared) and diffraction techniques. He works closely with colleagues at the ISIS Neutron Facility and at the Diamond Light Source, both situated at the Rutherford Appleton Laboratory in Oxfordshire. Selected papers:- Pressure-cooking of explosives - the crystal structure of -RDX as determined by X-ray and neutron diffraction. Chem. Commun., 2010, 46, 5662-5664.- Putting the squeeze on energetic materials - structural characterisation of a high-pressure phase of CL-20. CrystEngComm., 2010, 12, 2524-2527.- In-situ characterization of elusive salt hydrates - the crystal structures of the heptahydrate and octahydrate of sodium sulfate. J. Am. Chem. Soc., 2008, 130, 17795-17800.- The effect of a 10% carbamide peroxide bleaching agent on the phosphate concentration of tooth enamel assessed by Raman spectroscopy. Dental Traumatology, 2008, 24, 220-223.

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High Performance Liquid Chromatography (HPLC) is used to separate, identify, and quantify compounds. It is used by our group to quantify elution of monomers and other leachable components from adhesive systems and RBCs which may be of interest in biological interactions with the pulp tissue or even have a systemic effect.

Micro-Raman spectroscopy is used to quantify conversion of adhesive systems and resin-based composites (RBCs). Computerized platform allows linear and 2D mapping of e.g. RBC-adhesive or adhesive-tooth interface. It is possible to follow the distribution of components across various interfaces as well as calculate the degree of chemical changes in them, such as dentine demineralisation and adhesive ratio of double bonds.

Atomic Force Microscopy (AFM) is used to study surface characteristics of adhesives and RBCs and particularly their interfaces. Of particular interest is the force curve measurement which is used in contact mode to determine the adhesion force in a chosen single point. Current work using AFM includes measurements of surface roughness of novel RBCs after simulated mechanical, chemical and thermal aging.

Scanning electron microscopy (SEM) is used for surface imaging by scanning it with a high-energy beam of electrons in a raster scan pattern. Samples are dried using critical point drying method. In our current work, SEM is used to complement micro-Raman analysis of the RBC-adhesive-dentine interfaces.

Thermocouples (TC) are used to measure temperature based on the principle that a contact potential between two dissimilar metals changes as the temperature changes. Current work by our group is focused on temperature changes in the pulp chamber during light-curing of adhesives and RBCs. Curing of adhesives and RBCs results in temperature rise due to the exotherm nature of the polymerisation process and the heat generated by the light source.

Transmission electron microscopy (TEM) is a microscopy technique whereby a beam of electrons is transmitted through an ultra thin specimen, interacting with the specimen as it passes through. Alternate modes of use allow for the TEM to observe modulations in chemical identity, crystal orientation, electronic structure and sample induced electron phase shift as well as the regular absorption based imaging.

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Selected recent papers in refereed journals

Book chapter Santini A, Egle M and Miletic V. A review of SEM and TEM studies on the hybridisation of dentine. In: Microscopy: Science, Technology, Applications and Education. Editors: Mendez-Vilas A, Diaz J. Microscopy series No. 4, Volume 1, pages 256-268. Publisher: FORMATEX, Badajoz, Spain, 2011.ISBN-13: 978-84-614-6189-9. Click here to download

Miletic V, Santini A. Micro-Raman spectroscopic analysis of the degree of conversion of composite resins containing different initiators cured by polywave or monowave LED units. J Dent 2011 [In press]

Miletic V, Santini A. Micro-Raman Assessment of the Ratio of Carbon-Carbon Double Bonds of Two Adhesive Systems Cured with LED or Halogen Light-curing Units. J Adhes Dent 2010 Dec;12(6):461-7

Miletic V, Santini A, Trkulja I. Quantification of monomer elution and carbon-carbon double bonds in dental adhesive systems using HPLC and micro-Raman spectroscopy. J Dent 2009;37(3):177-84.

Santini A, Miletic V. Comparison of the hybrid layer formed by Silorane adhesive, one-step self-etch and etch and rinse systems using confocal micro-Raman spectroscopy and SEM. J Dent. 2008;36(9):683-91.

Miletic VJ, Santini A. Remaining unreacted methacrylate groups in resin-based composite with respect to sample preparation and storing conditions using micro-Raman spectroscopy. J Biomed Mater Res B Appl Biomater. 2008;87(2):468-74.

Santini A, Miletic V. Quantitative micro-Raman assessment of dentine demineralization, adhesive penetration, and degree of conversion of three dentine bonding systems. Eur J Oral Sci. 2008;116(2):177-83.

Santini A, Watterson C, Miletic V. Temperature rise within the pulp chamber during composite resin polymerisation using three different light sources. The Open Dentistry Journal 2008;2:137-141.

Durey K, Santini A, Miletic V. Pulp chamber temperature rise during curing of resin-based composites with different light-curing units. Prim Dent Care 2008;15(1):33-8.

Millen C, Ormond M, Richardson G, Santini A, Miletic V, Kew P. A study of temperature rise in the pulp chamber during composite polymerization with different light-curing units. J Contemp Dent Pract. 2007;8(7):29-37.

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